Caveolae-mediated Transcytosis
Gene co-expression module in Endothelial
| Category | Metabolite transfer |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
The top hub genes CAV1 and CAV2 encode caveolin-1 and caveolin-2, the structural proteins of caveolae — specialized lipid raft membrane invaginations critical for transcytosis, mechanosensing, and lipid metabolism in endothelial cells. EMP2 (epithelial membrane protein 2) regulates caveolae formation and is co-expressed with CAV1. HIF3A (hypoxia-inducible factor 3 alpha) adds a hypoxia/metabolic dimension. TXNIP is a thioredoxin-interacting protein involved in metabolic stress. ITGB5 (integrin beta-5) participates in caveolae-mediated endocytosis. ENAH (enabled homolog) regulates actin dynamics. SLC14A1 is a urea transporter. The module shows the strongest decrease in inflammation of this batch (delta UC -0.587), suggesting caveolae-mediated transcytosis is a major homeostatic endothelial function suppressed during IBD. Neighbor M25 and M26 are endothelial identity modules, supporting this as a related vascular functional program.
Genes
ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH, HIF3A, HMCN2, IGFBP2, ITGB5, KCNN3, KIAA1671, MFAP5, MGAT1, OFD1, PDGFD, SLC14A1, SLC25A4, SPRYD3, SYNE1, TACC1, TMEM47, TNFSF12, TXNIP, VAMP8, ZNF704
Most correlated modules
- Venous Endothelial Identity · correlation 0.86
- EC Quiescence Identity · correlation 0.84
- Arterial EC Identity · correlation 0.78
- MHC Class I Presentation · correlation 0.76
- NF-kB Chromatin Regulation · correlation 0.75
- Capillary Endothelial Identity · correlation 0.74
- Endothelial Lipid Signaling · correlation 0.73
- Vascular Homeostasis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.