ENSA — Endosulfine alpha
ENSA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENSA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENY2, FBXL14 +18 more | |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, FEZ2, GSN, PDLIM3, PON2 +9 more | View in SCUBA |
About the gene
| Synonyms | ARPP-19e, MGC4319, MGC78563, MGC8394 |
|---|---|
| Chromosome | 1: 150600851-150629612 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Protein phosphatase inhibitor |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.