AIMP1 — Aminoacyl tRNA synthetase complex interacting multifunctional protein 1
AIMP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AIMP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2, FBXL14 +18 more | |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1, CHCHD5 +38 more | View in SCUBA |
About the gene
| Synonyms | EMAP-2, EMAPII, p43, SCYE1 |
|---|---|
| Chromosome | 4: 106315544-106349456 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine, RNA-binding, tRNA-binding |
| Biological process | Angiogenesis, Apoptosis, Inflammatory response, Protein biosynthesis |
Function
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7- mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.