RNA Binding/Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 27 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 27 genes have a known function matching the annotation |
Why this annotation
Hub gene SSB encodes La antigen, a canonical RNA-binding protein involved in RNA processing and splicing. RBM14 (core member) and RBM4 are splicing regulators. ISY1 is a spliceosome-associated factor. SLBP binds histone mRNA stem-loops (RNA processing). POLR2K is an RNA polymerase II subunit. SRP19 is part of the signal recognition particle (co-translational targeting). HSF1 (heat shock transcription factor) adds a stress/proteostasis dimension. UBE2A and UBE2R2 are E2 ubiquitin-conjugating enzymes and USP22 is a deubiquitinase, suggesting ubiquitin-mediated regulation of RNA processing factors. Overall: RNA binding and splicing regulation with ubiquitin co-regulation.
Genes
AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2, FBXL14, HSF1, ISY1, LLPH, POLR2K, PTDSS1, PTOV1, RBM14, RBM4, SLBP, SLIRP, SRA1, SRP19, SSB, SUGT1, TRIM28, UBE2A, UBE2R2, USP22
Most correlated modules
- ER Protein Biogenesis · correlation 0.85
- Transcriptional Repressor Complex · correlation 0.85
- Autophagy Stress Response · correlation 0.84
- Mitochondrial ETC · correlation 0.80
- RNA Surveillance/NMD · correlation 0.79
- T Cell Phosphatase Signaling · correlation 0.78
- snRNP Splicing · correlation 0.78
- Chromatin-Splicing Regulation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.