IFN-gamma Antigen Processing
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes GBP3 (guanylate-binding protein, IFN-gamma-induced), PSMB9 (immunoproteasome beta subunit, IFN-gamma-induced), TAP2 (transporter associated with antigen processing), PSMB8 (immunoproteasome), UBE2L6 (ISG15 conjugating enzyme), STAT1 (master IFN-gamma transcription factor), SAMD9L (ISG), IFI35 (interferon-induced), PSME1 (PA28 proteasome activator), RNF213 (ISG/moyamoya gene), OAS1 (ISG), and ERAP2 (ER aminopeptidase, MHC-I peptide trimming) are all canonical IFN-gamma-stimulated genes involved in antigen processing and immunoproteasome function. The module is significantly upregulated in CD inflammation. Neighbor context: this module bridges M103 (ISG/innate) and M143/M136 (MHC presentation), representing the IFN-gamma-driven immunoproteasome/antigen processing arm of the interferon response cluster.
Genes
ERAP2, GBP3, IFI35, OAS1, PSMB8, PSMB9, PSME1, RNF213, SAMD9L, STAT1, TAP2, UBE2L6
Most correlated modules
- Type I Interferon Response · correlation 0.85
- IFN-gamma Response · correlation 0.84
- MHC Class I Presentation · correlation 0.69
- Type I Interferon · correlation 0.63
- MHC Class II Presentation · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.