SCUBA

SAMD9L — Sterile alpha motif domain containing 9 like

SAMD9L belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SAMD9L's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsType I Interferon
Anti-viral
GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1 +9 moreView in SCUBA
CD4⁺ T cellsJAK-STAT Signaling
Immune regulation
ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, JAK3, MBNL1 +7 moreView in SCUBA
CD8⁺ T cellsInterferon-stimulated Genes
Inflammation
ADAR, GBP1, OAS2, PARP14, PARP9, RNF213, SAMD9, SP110 +3 moreView in SCUBA
EndothelialIFN-gamma Antigen Processing
Inflammation
ERAP2, GBP3, IFI35, OAS1, PSMB8, PSMB9, PSME1, RNF213 +3 moreView in SCUBA
EnterocytesEpithelial junction adhesion
Migration & adhesion
ADGRG6, CEACAM6, CTNNB1, DSG2, KTN1, NCOA7, SH3GLB1, TOP1 +2 moreView in SCUBA
Gamma-delta T cellsAntiviral ISG Response
Inflammation
ACTR1A, ATRX, CD164, CYTH4, FGD3, GIT2, LASP1, PARP10 +6 more
MacrophagesAntiviral ISG Response
Antiviral
ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 moreView in SCUBA
MonocytesIFN-gamma Response
Antiviral
APOL2, APOL6, CXCL10, ETV7, GBP1, GBP4, GBP5, IFIH1 +6 moreView in SCUBA
Mucosal-associated invariant T cellType I Interferon
Inflammation
DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more

About the gene

SynonymsC7orf6, FLJ39885, KIAA2005
Chromosome7: 93130056-93148385
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Predicted intracellular proteins

Function

May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.