RAB2A — RAB2A, member RAS oncogene family
RAB2A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Rho-Actin Remodeling Cytoskeletal | ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B +9 more | View in SCUBA |
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ANXA5, ARF1, ATP6AP2, MORF4L1, MTDH, OCIAD1, PTGES3, SELENOF +6 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5 +8 more | View in SCUBA |
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC +13 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Smooth muscle cells | Actin Dynamics Housekeeping Housekeeping | C12orf75, CAPZA2, CFL1, ELN, ENY2, PPIA, PRDX1, PSMB1 +3 more | View in SCUBA |
About the gene
| Synonyms | RAB2 |
|---|---|
| Chromosome | 8: 60516936-60623644 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. Together with RAB2B, redundantly required for efficient autophagic flux.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.