GDF11 — Growth differentiation factor 11
GDF11 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GDF11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Chromatin Remodeling Stemness | CBX3, EIF3A, EIF5B, HNRNPM, NMNAT3, RFX7, RIF1, SMARCC1 +4 more | |
| Smooth muscle cells | Immediate Early Response Stress | ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, HEXIM1, IER5 +4 more | View in SCUBA |
About the gene
| Synonyms | BMP-11, BMP11 |
|---|---|
| Chromosome | 12: 55743122-55757264 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor |
Function
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.