ARL5B — ADP ribosylation factor like GTPase 5B

ARL5B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARL5B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, IER2, NFKBIA, PPP1R15B +3 more	View in SCUBA
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ATF3, CSRNP1, NFKBIZ, PPP1R15B, RASGEF1B, TIPARP, TNFAIP3 +2 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1, KDM6B +3 more	View in SCUBA
Fibroblasts	Proteotoxic Stress Survival Stress	BAG3, DNAJA4, ICAM1, PPIF, PPP1R15B, SLC25A25, TIPARP, TNFRSF10D	View in SCUBA
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2, JOSD1 +12 more	View in SCUBA
Macrophages	NF-κB Effector Response Inflammatory	BIRC3, CYB5D1, DUSP2, EGR3, HES1, ICAM4, PTGS2, SIK1	View in SCUBA
Monocytes	Inflammatory Stress Response Stress	ATF3, CCRL2, CD83, DUSP10, IL1B, NFE2L2, RASGEF1B, SGK1 +2 more	View in SCUBA
Natural Killer cells	NF-κB Activation Inflammation	BIRC3, CD83, KDM6B, NFKBID, NR4A1, NR4A3, RASGEF1B, REL	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65, JOSD1 +4 more
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, BRD2, DDIT3, EGR3, GDF11, HEXIM1, IER5 +4 more	View in SCUBA

About the gene

Synonyms	ARL8
Chromosome	10: 18659431-18681639
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Binds and exchanges GTP and GDP

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.