IER5 — Immediate early response 5

IER5 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IER5's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2 +6 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, JUN, KLF6 +6 more	View in SCUBA
Endothelial	Heat Shock Response Stress	BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18 +2 more	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, MIDN +5 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	AMD1, DBF4, DNAJB9, DUSP2, NFKBIB, NINJ1, PHLDA1, PMAIP1 +5 more
Glial cells	DNA Damage Response Stress	BRD2, FAM53C, GADD45B, ING1, NFKBIZ, PABPC1, SRSF3, TUBB4B +1 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Lymphatic endothelial	Lymphatic Valve Formation Valve formation	CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HES5 +9 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Mucosal-associated invariant T cell	Dissociation Stress Response Stress	DUSP1, EIF1, FOS, H3-3B, SAT1, SRSF3, SRSF7
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, MARCKSL1, NFKBIA, NFKBIZ, PMAIP1, PPP1R15A, PPP1R15B +1 more	View in SCUBA
Neutrophils	Chemokine Secretion Cytokine & chemokine secretion	CXCL1, CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, MAFF +3 more
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, GDF11, HEXIM1 +4 more	View in SCUBA

About the gene

Chromosome	1: 181088700-181092900
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator, Repressor
Biological process	Stress response, Transcription, Transcription regulation

Function

Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.