SMARCC1 — SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
SMARCC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMARCC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | CCAR1, ENAH, FNBP1L, KDM1A, LMO4, PAIP1, PBRM1, RHOBTB3 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Chromatin Remodeling Stemness | CBX3, EIF3A, EIF5B, GDF11, HNRNPM, NMNAT3, RFX7, RIF1 +4 more | |
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ARCN1, ATL3, CASP8, CYFIP2, DENND4C, DIDO1, DPP4, ERAP1 +8 more |
About the gene
| Synonyms | BAF155, CRACC1, Rsc8, SRG3 |
|---|---|
| Chromosome | 3: 47585269-47782106 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.