Immediate Early Response
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are the canonical P-TEFb/pause-release and immediate-early stress transcription set: HEXIM1 (7SK snRNP inhibitor of P-TEFb), BRD2 and INTS6 (Integrator, transcriptional pausing/termination), SERTAD1 (TRIP-Br, CDK4/E2F-linked IEG), plus classic IEGs ARC, IER5, EGR3, PLK2, MAFF and the ISR/CHOP effector DDIT3. This is the stereotypical dissociation/handling-induced immediate-early transcriptional burst rather than a lineage program, consistent with uniform expression across all SMC subsets and moderate detection rate. Its neighbors (M43 cytoskeletal scaffolding, M4 lipid/mRNA-surveillance) are low-amplitude housekeeping-type modules, so co-expression likely reflects a shared global transcriptional-rate axis; the IEG/HEXIM1 identity is unambiguous here.
Genes
ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, GDF11, HEXIM1, IER5, INTS6, MAFF, PLK2, SERTAD1
Most correlated modules
- Heat Shock Response · correlation 0.91
- NO-cGMP Signaling · correlation 0.70
- Immediate Early Response · correlation 0.70
- HOX Positional Identity · correlation 0.68
- Notch-TGFbeta Signaling · correlation 0.67
- Pericyte Signature · correlation 0.67
- BAG3-HSPB8 proteostasis · correlation 0.64
- Translation initiation/RNA-binding · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.