EIF5B — Eukaryotic translation initiation factor 5B
EIF5B belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF5B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome/translation Protein processing & ER | ANP32E, CDC123, EIF4E, EMC8, MRPL20, NME7, PDXK, PKM +9 more | View in SCUBA |
| Endothelial | Endothelial NO Activation Endothelial cell development | BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDAH2, DDX46 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Chromatin Remodeling Stemness | CBX3, EIF3A, GDF11, HNRNPM, NMNAT3, RFX7, RIF1, SMARCC1 +4 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EMC4, EPRS1 +31 more | View in SCUBA |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, COX7A2L, GABARAPL2, LAMTOR4, NDUFAB1, PGAM1, SPCS2, TMEM14C +2 more | View in SCUBA |
About the gene
| Synonyms | DKFZp434I036, FLJ10524, IF2, KIAA0741 |
|---|---|
| Chromosome | 2: 99337371-99401326 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Initiation factor |
| Biological process | Protein biosynthesis |
Function
Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation- competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.