Oxidative Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
S100A6 and S100A11 are calcium-binding S100 proteins upregulated in inflammatory and stress contexts in endothelial cells. TSPO (translocator protein) is a mitochondrial outer membrane protein involved in oxidative stress and inflammatory signaling. NFE2L1 (NRF1) is a transcription factor regulating oxidative stress response. AHR (aryl hydrocarbon receptor) responds to oxidative/xenobiotic stress and regulates inflammatory gene expression. HYAL2 is a hyaluronidase involved in ECM remodeling and inflammatory signaling. ITPR3 mediates IP3-dependent calcium release. SERPINB6 is a protease inhibitor upregulated under stress. CD59 inhibits complement membrane attack complex. TAGLN2 and DSTN regulate actin dynamics. ITGA3 mediates cell-matrix adhesion. FLOT2 is a lipid raft/flotillin protein. The module reflects an oxidative and inflammatory stress response with calcium signaling, moderately upregulated in IBD.
Genes
AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5, HYAL2, ITGA3, ITPR3, MGST3, NFE2L1, NUDT14, S100A11, S100A6, SEC11C, SERPINB6, TAGLN2, TSPO
Most correlated modules
- Hippo-YAP Cytoskeletal · correlation 0.86
- IL-13/STAT6 Signaling · correlation 0.82
- ER-Golgi Trafficking · correlation 0.80
- Endothelial NO Activation · correlation 0.77
- Vascular Tone Regulation · correlation 0.74
- TRAIL-mediated Apoptosis · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.