HAS2 — Hyaluronan synthase 2
HAS2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HAS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Hyaluronan-CD44 Remodeling ECM remodeling | C4orf48, CBX3, CD44, HES4, MIA, PLEKHA4, WWTR1 | View in SCUBA |
About the gene
| Chromosome | 8: 121612116-121641440 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.