WWTR1 — WW domain containing transcription regulator 1
WWTR1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WWTR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2 +10 more | View in SCUBA |
| Fibroblasts | Heparan Sulfate Remodeling ECM remodeling | ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, JMJD1C +11 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Glial cells | Hyaluronan-CD44 Remodeling ECM remodeling | C4orf48, CBX3, CD44, HAS2, HES4, MIA, PLEKHA4 | View in SCUBA |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RAI14 +4 more | View in SCUBA |
| Pericytes | YAP/TAZ Mechanosensing Developmental | CARHSP1, COL15A1, ENG, MLEC, NOL4L, TMEM204, TRIOBP, VAT1 +1 more | View in SCUBA |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9 +5 more | View in SCUBA |
About the gene
| Synonyms | DKFZp586I1419, TAZ |
|---|---|
| Chromosome | 3: 149517235-149736714 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.