IBTK — Inhibitor of Bruton tyrosine kinase
IBTK belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IBTK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3 +15 more | View in SCUBA |
About the gene
| Synonyms | BTBD26, BTKI, DKFZP564B116 |
|---|---|
| Chromosome | 6: 82169986-82247754 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.