ATP6AP2 — ATPase H+ transporting accessory protein 2
ATP6AP2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6AP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ANXA5, ARF1, MORF4L1, MTDH, OCIAD1, PTGES3, RAB2A, SELENOF +6 more | View in SCUBA |
| Innate lymphoid cells | Protein Biogenesis & Import Protein processing & ER | ANAPC16, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5, S100A4 +6 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity endothelial development | BEX3, CD151, FDPS, GNG11, LMO2, MGST3, NAA38, POLR2L +2 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6V0B, ATP6V0E1, AUP1, BCAP31, BSG +41 more | View in SCUBA |
| Smooth muscle cells | Membrane Protein Turnover Housekeeping | AXL, BSG, CAP1, CBX6, EI24, MFAP4, SSR2, TCEAL9 +1 more | View in SCUBA |
About the gene
| Synonyms | APT6M8-9, ATP6IP2, ATP6M8-9, M8-9, PRR, RENR |
|---|---|
| Chromosome | X: 40579372-40606848 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
Function
Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v- ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.