FRMD4B — FERM domain containing 4B
FRMD4B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRMD4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chemokine Migration migration & adhesion | CCR6, CYTIP, DDX24, G3BP2, GNG2, GPBP1, KMT2E, PDE4B +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CERS6, CHST15, DOCK5, EPS15, FRY, IL7, ITSN1 +4 more | View in SCUBA |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ADAP2, ARHGAP18, CD84, GNPDA1, LIPA, MAF, MRC1 | View in SCUBA |
About the gene
| Synonyms | GRSP1, KIAA1013 |
|---|---|
| Chromosome | 3: 69168782-69542583 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.