FRY — FRY microtubule binding protein
FRY belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRY's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Fibroblast Niche Identity Developmental | ALKAL2, AMPD3, CHST1, CNTFR, COL4A6, CTTNBP2, CXCR4, DDHD1 +10 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Progenitor Granulocyte development | CD84, CPA3, GATA2, HPGDS, IKZF2, NLK, REXO5, RRBP1 +2 more | |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CERS6, CHST15, DOCK5, EPS15, FRMD4B, IL7, ITSN1 +4 more | View in SCUBA |
| Neutrophils | Degranulation Trafficking Degranulation | ATP11A, BIN2, CSGALNACT2, KDM7A, LPGAT1, PYGL, RAB27A, RIN3 +7 more | |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, EBF1, FRMD4A, ITGA7, LGALSL, LGI4, MCAM, MEF2C +6 more | View in SCUBA |
About the gene
| Synonyms | 13CDNA73, bA37E23.1, C13orf14, CG003 |
|---|---|
| Chromosome | 13: 31846713-32299125 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.