KIF2C — Kinesin family member 2C
KIF2C belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF2C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDCA8, CDK1, NDC80, NUF2, NUSAP1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | ASPM, CDCA8, GTSE1, KIF15, KIF4A, NCAPG, NUSAP1, SPC25 +2 more |
About the gene
| Synonyms | CT139, KNSL6, MCAK |
|---|---|
| Chromosome | 1: 44739818-44767767 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis |
Function
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.