Mitotic Spindle
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes ASPM (mitotic spindle pole), NCAPG (condensin, chromosome condensation), KIF15 (kinesin, bipolar spindle), UBE2C (APC/C ubiquitin ligase, mitotic exit), TOP2A (topoisomerase II, chromosome condensation/segregation), KIF2C (kinesin, microtubule depolymerization at kinetochore), CDCA8/Borealin (chromosomal passenger complex), KIF4A (kinesin, chromosome alignment), GTSE1 (G2/M, microtubule stabilization), SPC25 (kinetochore), NUSAP1 (microtubule/chromatin, mitosis). This is a highly coherent mitotic spindle/chromosome segregation module representing M-phase execution. All genes function in spindle assembly, chromosome condensation/segregation, or mitotic exit. Neighbor to M35 (spindle checkpoint) confirms this is the M-phase execution arm of the cell-cycle module cluster.
Genes
ASPM, CDCA8, GTSE1, KIF15, KIF2C, KIF4A, NCAPG, NUSAP1, SPC25, TOP2A, UBE2C
Most correlated modules
- Mitotic Spindle · correlation 0.97
- Late S-phase G2 Entry · correlation 0.89
- Mitotic Spindle Checkpoint · correlation 0.87
- S-phase Progression · correlation 0.74
- Replication Origin Licensing · correlation 0.70
- DNA Replication S-phase · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.