CDCA8 — Cell division cycle associated 8
CDCA8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDCA8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDK1, KIF2C, NDC80, NUF2, NUSAP1 +3 more | View in SCUBA |
| CD8⁺ T cells | G2/M Cell Cycle Cell cycle | CCNF, CDC25C, CDCA3, DEPDC1B, FAM83D, FBXO43, HJURP, PRC1 +1 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CENPE, CENPF, CKS1B, EZH2, MAD2L1, MKI67 +12 more | |
| Goblet cells | Chromosome Segregation Cell cycle | ANLN, CDCA2, CKAP2L, HJURP, KIF11, KIFC1, NCAPG, NDC80 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | ASPM, GTSE1, KIF15, KIF2C, KIF4A, NCAPG, NUSAP1, SPC25 +2 more |
About the gene
| Synonyms | BOR, DasraB, FLJ12042, MESRGP |
|---|---|
| Chromosome | 1: 37692481-37709719 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.