SPC25 — SPC25 component of NDC80 kinetochore complex
SPC25 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPC25's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, CENPA +7 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Assembly Cell cycle | FBXO5, LRR1, MELK, MTFR2, NCAPG2, RAD51AP1, SHCBP1, SKA1 +3 more | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, E2F8, ESCO2, FOXM1, IQGAP3, MELK +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | ASPM, CDCA8, GTSE1, KIF15, KIF2C, KIF4A, NCAPG, NUSAP1 +2 more | |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG +4 more | View in SCUBA |
About the gene
| Synonyms | AD024, MGC22228, SPBC25 |
|---|---|
| Chromosome | 2: 168834132-168913371 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.