KIF4A — Kinesin family member 4A
KIF4A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Spindle Bipolarity Cytokinesis Cell cycle | ANLN, ARHGAP11A, BUB1B, C21orf58, CIT, DIAPH3, ECT2, KIF11 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | ASPM, CDCA8, GTSE1, KIF15, KIF2C, NCAPG, NUSAP1, SPC25 +2 more |
About the gene
| Synonyms | FLJ12530, FLJ12655, FLJ14204, FLJ20631, HSA271784, KIF4, KIF4-G1, MRX100 |
|---|---|
| Chromosome | X: 70290104-70420886 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding, Motor protein |
Function
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.