KLHL42 — Kelch like family member 42
KLHL42 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLHL42's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Vesicle Trafficking Cytoskeletal | ABRACL, ACTR3, ADRM1, ANKRD9, C3orf14, CISD2, CLIC1, EIF2S1 +10 more | View in SCUBA |
| Smooth muscle cells | Integrin adhesion complex Migration & adhesion | ALDH1B1, ALDH2, DST, FERMT2, ITGA5, METTL7A, NFIX, NPTN +3 more | View in SCUBA |
About the gene
| Synonyms | Ctb9, KIAA1340, KLHDC5 |
|---|---|
| Chromosome | 12: 27780048-27803040 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.