NPTN — Neuroplastin
NPTN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPTN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, DOCK1, ERC1 +6 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1 +8 more | View in SCUBA |
| Gamma-delta T cells | ER-Lysosomal Trafficking Protein processing & ER | ARL6IP5, ATF6B, BORCS6, CD53, CLN3, DHRS7, MGAT1, MMP23B +12 more | |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
| Smooth muscle cells | Integrin adhesion complex Migration & adhesion | ALDH1B1, ALDH2, DST, FERMT2, ITGA5, KLHL42, METTL7A, NFIX +3 more | View in SCUBA |
About the gene
| Synonyms | GP55, GP65, np55, np65, SDFR1, SDR1 |
|---|---|
| Chromosome | 15: 73560014-73634134 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Cell adhesion, Neurogenesis |
Function
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.