LAMP3 — Lysosomal associated membrane protein 3
LAMP3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation ECM remodeling | C4orf48, CAPG, CD200, COL6A1, COL6A2, IGFBP5, NT5E, OAF +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HELZ2, HERC6, IFIT1, LGALS9, MX2, OAS3, PLSCR1 +2 more |
About the gene
| Synonyms | CD208, DC-LAMP, DCLAMP, LAMP, TSC403 |
|---|---|
| Chromosome | 3: 183122215-183163839 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Host-virus interaction, Immunity |
Function
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.