LRRC25 — Leucine rich repeat containing 25
LRRC25 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRRC25's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Lysosomal & pahgocytosis | ABI3, CAMK1, CD300A, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2 +5 more | View in SCUBA |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, CAMK4, GPR34, GPR55, ITGAE, MYO1E, NCR2, S100A13 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ38116, MAPA |
|---|---|
| Chromosome | 19: 18391137-18397622 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.