GPR34 — G protein-coupled receptor 34
GPR34 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR34's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, MAEA, MGAT1 +7 more | View in SCUBA |
| CD8⁺ T cells | Tc17 program Tc17 program | ABI3, ABRACL, CAPG, CCDC85B, FKBP11, IL17A, KLRB1, NFKBIA +4 more | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, AKR1B1, CPM, FCHO2, MERTK, PDK4, SLC1A3, STARD13 | View in SCUBA |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, CAMK4, GPR55, ITGAE, LRRC25, MYO1E, NCR2, S100A13 +2 more | View in SCUBA |
About the gene
| Chromosome | X: 41688973-41697275 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.