S100A13 — S100 calcium binding protein A13
S100A13 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S100A13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Identity Endothelial cell development | CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7 +7 more | View in SCUBA |
| Goblet cells | S100 Calcium Signaling Stress | CIB1, CLDN7, CLTB, GUK1, MYL12B, MYL6, RHOC, S100A11 +4 more | View in SCUBA |
| Innate lymphoid cells | NK/ILC1 Identity Differentiation | ABCA5, ARHGAP15, CD37, CD96, CD99, CTSD, EPC1, GIMAP2 +17 more | View in SCUBA |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, CAMK4, GPR34, GPR55, ITGAE, LRRC25, MYO1E, NCR2 +2 more | View in SCUBA |
| Smooth muscle cells | Matrisome Regulators ECM remodeling | ITM2C, LPP, LUM, NBL1, PMP22, TCEAL4, TIMP2, TMEM176B +1 more | View in SCUBA |
About the gene
| Chromosome | 1: 153618787-153631360 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Protein transport, Transport |
Function
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.