LRRC32 — Leucine rich repeat containing 32
LRRC32 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRRC32's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, ASAP1, GRK5, MYH9, RAPGEF2, RFTN1, SERPINH1, TCEAL9 +2 more | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more | View in SCUBA |
About the gene
| Synonyms | D11S833E, GARP |
|---|---|
| Chromosome | 11: 76657524-76670747 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Growth factor binding |
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.