TGF-β Cytoskeletal Remodeling
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene RFTN1 (raftlin) is a lipid raft scaffold protein involved in B-cell receptor signaling and membrane organization. ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) is an Arf GTPase-activating protein that regulates actin cytoskeleton, focal adhesions, and cell migration. MYH9 (non-muscle myosin IIA heavy chain) is a major cytoskeletal motor protein involved in cell migration, adhesion, and mechanosensing. GRK5 (G protein-coupled receptor kinase 5) regulates GPCR signaling and has roles in cardiac hypertrophy and inflammation. RAPGEF2 (Rap guanine nucleotide exchange factor 2) activates Rap1 GTPases involved in cell adhesion and migration. ZMIZ1 is a transcriptional coactivator (PIAS-like) involved in TGF-β and Notch signaling. LRRC32 (GARP) is a TGF-β activator on the cell surface. ARHGEF12 (LARG) is a RhoA GEF involved in cytoskeletal regulation. SERPINH1 (HSP47) is a collagen-specific chaperone involved in collagen folding and fibrosis. TCEAL9 is a transcription elongation factor. UACA is involved in apoptosis regulation. The combination of cytoskeletal regulators (MYH9, ASAP1, ARHGEF12, RAPGEF2), TGF-β pathway components (LRRC32/GARP, ZMIZ1), and SERPINH1 (collagen chaperone) suggests a pericyte activation/TGF-β-driven cytoskeletal remodeling program. The moderate coherence and multiple moderate-membership hub genes suggest a mixed program combining cytoskeletal dynamics with TGF-β signaling. Concordant cytoskeletal/TGF-β/migration genes: RFTN1, ASAP1, MYH9, RAPGEF2, ARHGEF12, LRRC32, ZMIZ1, SERPINH1 (8/11).
Genes
ARHGEF12, ASAP1, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, SERPINH1, TCEAL9, UACA, ZMIZ1
Most correlated modules
- Inflammatory ECM Remodeling · correlation 0.86
- Basement Membrane Assembly · correlation 0.83
- ER Chaperone UPR · correlation 0.82
- ER Stress Response · correlation 0.81
- NF-κB Inflammatory Activation · correlation 0.79
- ER Protein Folding · correlation 0.78
- BM Collagen Production · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.