RAPGEF2 — Rap guanine nucleotide exchange factor 2
RAPGEF2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAPGEF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, BRAF, CPNE8, DENND4A, ELF2, FBXO11, FNDC3B, GRB10 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Tissue residence | ACSL1, AMFR, CRACDL, DHX36, HES4, IRF8, ITGAE, LZTFL1 +8 more | |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, ASAP1, GRK5, LRRC32, MYH9, RFTN1, SERPINH1, TCEAL9 +2 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal lncRNA Activation Activation | AES, C20orf27, CAVIN2, CYTOR, LHFPL6, MIR4435-2HG, MSC-AS1, SEPT11 +2 more | View in SCUBA |
About the gene
| Synonyms | DKFZP586O1422, KIAA0313, PDZ-GEF1, PDZGEF1, RA-GEF |
|---|---|
| Chromosome | 4: 159103013-159360174 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein, GTPase activation, Guanine-nucleotide releasing factor |
| Biological process | Differentiation, Neurogenesis |
Function
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP- independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.