MARCHF9 — Membrane associated ring-CH-type finger 9
MARCHF9 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MARCHF9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2 +11 more | |
| Mucosal-associated invariant T cell | T cell Identity T cell maturation | ARPC1B, BLOC1S1, C4orf3, CD3D, CHKB, CPNE1, DDX39B, HMGN3 +9 more |
About the gene
| Synonyms | FLJ36578, MARCH9, RNF179 |
|---|---|
| Chromosome | 12: 57755103-57760411 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.