CD3D — CD3 delta subunit of T-cell receptor complex
CD3D belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD3D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3E, CD3G, CD81, CERK +14 more | View in SCUBA |
| CD8⁺ T cells | Gut Tissue Residency Gut residence | ALOX5AP, C4orf3, CAPN2, CD164, CD7, CD99, CLIC3, ID2 +9 more | View in SCUBA |
| Gamma-delta T cells | TCR Vesicular Trafficking TCR Signaling | ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3G, CD99, FKBP8 +14 more | |
| Mucosal-associated invariant T cell | T cell Identity T cell maturation | ARPC1B, BLOC1S1, C4orf3, CHKB, CPNE1, DDX39B, HMGN3, MARCHF9 +9 more |
About the gene
| Synonyms | CD3-DELTA, CD3DELTA, T3D |
|---|---|
| Chromosome | 11: 118339075-118342705 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.