T cell Identity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 18 genes have a known function matching the annotation |
Why this annotation
CD3D is a canonical TCR complex component and a defining marker of T cells including MAITs. MICOS10 (mitochondrial inner membrane organizing system), ARPC1B (Arp2/3 actin branching), WASHC3 (WASH complex/endosomal actin), BLOC1S1 (lysosome-related organelle biogenesis), DDX39B (RNA helicase/mRNA export), HMGN3 (chromatin remodeling), POLR3GL (RNA pol III), RBX1 (SCF E3 ubiquitin ligase), MARCHF9 (E3 ubiquitin ligase/membrane protein degradation) are mostly housekeeping. Despite mixed composition, CD3D as a hub gene and the uniform MAIT expression suggest this captures constitutive T cell identity alongside general cellular machinery.
Genes
ARPC1B, BLOC1S1, C4orf3, CD3D, CHKB, CPNE1, DDX39B, HMGN3, MARCHF9, MICOS10, OXLD1, POLR3GL, RBX1, RNF34, ROMO1, SPSB3, WASHC3, ZNF862
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.91
- Mitochondrial Housekeeping · correlation 0.91
- T cell Homeostasis · correlation 0.87
- ER & Mitochondrial Assembly · correlation 0.87
- Mitochondrial OxPhos · correlation 0.85
- Leukocyte Housekeeping · correlation 0.83
- MAIT Effector Maturation · correlation 0.83
- Oxidative Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.