IER3IP1 — Immediate early response 3 interacting protein 1
IER3IP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IER3IP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IL2RG, KLRK1, KRTCAP2, LAMTOR4 +11 more | |
| Innate lymphoid cells | Mitochondrial Lysosomal Housekeeping Mitochondrial & OxPhos | BTF3L4, C14orf119, EMC6, ETFA, JTB, LAMP1, MRPL14, MRPS16 +7 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
About the gene
| Chromosome | 18: 47152834-47176364 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Protein transport, Transport |
Function
Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.