NKG2D Cytotoxic Activation
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes include IL2RG (common gamma chain of IL-2/IL-4/IL-7/IL-15/IL-21 receptors), KLRK1 (NKG2D activating receptor critical for cytotoxicity), HCST (DAP10, obligate signaling adaptor for NKG2D), and TNFSF12 (TWEAK cytokine). KLRK1+HCST together constitute the NKG2D receptor-adaptor complex that drives cytotoxic killing in gd T cells and NK cells. MARCHF9 mediates MHC-I downregulation. GABARAP links to autophagy and possibly unconventional secretion. NDUFC2 indicates metabolic support. CCND3 suggests mild proliferative activity. IL2RG supports cytokine-driven survival/expansion. This module captures NKG2D-mediated cytotoxic activation of gd T cells.
Genes
CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2, LAMTOR4, MARCHF9, MGST3, MOGS, NDUFC2, RAB4B, RNASEK, SNX15, TMEM59, TNFSF12, TRAPPC5, UBE2V1
Most correlated modules
- Lymphocyte Homeostatic Regulation · correlation 0.89
- TCR Vesicular Trafficking · correlation 0.89
- T-bet Effector Differentiation · correlation 0.89
- T Cell Homeostasis · correlation 0.88
- Protein Homeostasis Chaperones · correlation 0.85
- Oxidative Phosphorylation · correlation 0.82
- Basal Cell Maintenance · correlation 0.82
- Effector Cell Migration · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.