MCF2L — MCF.2 cell line derived transforming sequence like
MCF2L belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCF2L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6 +8 more | View in SCUBA |
| Pericytes | BMP-SMAD Signaling Developmental | CTSH, ETS2, EXOC3L2, IL3RA, ITM2A, NDST1, PDE2A, SCARB1 +3 more | View in SCUBA |
About the gene
| Synonyms | ARHGEF14, DBS, KIAA0362, OST |
|---|---|
| Chromosome | 13: 112894378-113099742 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. Does not catalyze guanine nucleotide exchange on CDC42
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.