MNDA — Myeloid cell nuclear differentiation antigen
MNDA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MNDA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Type I Interferon Anti-viral | GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MX1, MX2 +9 more | View in SCUBA |
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HNMT +10 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, GAPT, LYST, MAP3K1, POU2F2, RGS18, SLC24A4, TMEM154 +4 more | View in SCUBA |
| Neutrophils | Neutrophil Differentiation Developmental | ABTB1, FRAT2, GCA, ICAM3, MANSC1, MSL3, NFE2, QPCT +2 more |
About the gene
| Synonyms | PYHIN3 |
|---|---|
| Chromosome | 1: 158831351-158849506 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.