Type I Interferon
Gene co-expression module in CD19⁺ B cells
| Category | Anti-viral |
|---|---|
| Genes | 18 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes are classic interferon-stimulated genes: MX2, MX1, XAF1, STAT1, SAMD9L, RNF213, LY6E, TRIM22, ISG15, ISG20, TAP1, IRF9, GBP2/4, PARP14. This is a canonical type I interferon antiviral response, upregulated with inflammation in both UC and CD.
Genes
GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1, MX2, PARP14, RNF213, SAMD9L, SOD2, STAT1, TAP1, TENT5A, TRIM22, XAF1
Most correlated modules
- Antiviral Restriction · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.