MTAP — Methylthioadenosine phosphorylase
MTAP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Dynamics Mitochondrial & OxPhos | ATP5MC1, ECHS1, EDF1, FIS1, FRA10AC1, HIGD2A, IFNAR2, MICOS13 +2 more | |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GOPC, GRAP2, IRF2, LPAR5, PDCD10, SENP7, SYNRG +3 more |
About the gene
| Synonyms | c86fus, MSAP |
|---|---|
| Chromosome | 9: 21802636-21937651 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Purine salvage |
Function
Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.