GRAP2 — GRB2 related adaptor protein 2
GRAP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cell motility/adhesion migration & adhesion | ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GYG1, ITM2B, LCP1 +14 more | View in SCUBA |
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more | |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GOPC, IRF2, LPAR5, MTAP, PDCD10, SENP7, SYNRG +3 more | |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GZMH, LIME1, LYAR, RGS9, SSBP3, SYT11 +1 more | View in SCUBA |
About the gene
| Synonyms | GADS, GRBLG, GrbX, Grf40, Mona |
|---|---|
| Chromosome | 22: 39901084-39973721 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.