SYNRG — Synergin gamma
SYNRG belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYNRG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Gamma-delta T cells | T cell Survival T cell maturation | ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS +26 more | |
| Innate lymphoid cells | Golgi RNA Processing RNA processing & translation | ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MIA2, MSI2, NR2C2 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GOPC, GRAP2, IRF2, LPAR5, MTAP, PDCD10, SENP7 +3 more | |
| Natural Killer cells | NK Homeostatic Survival Immune regulation | ACAP1, ARHGAP30, CAPN12, FYB1, GIMAP6, GPR174, IRF2, SLFN5 +1 more | View in SCUBA |
About the gene
| Synonyms | AP1GBP1, MGC104959, SYNG |
|---|---|
| Chromosome | 17: 37514807-37609472 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Endocytosis, Protein transport, Transport |
Function
Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP- 1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.