SENP7 — SUMO specific peptidase 7
SENP7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SENP7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Interferon Antiviral Response Inflammation | ANKRD44, DDX17, DDX60L, IARS2, KIAA0319L, KRBOX5, LZIC, MIA2 +14 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | BAZ2B, CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB +4 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GOPC, GRAP2, IRF2, LPAR5, MTAP, PDCD10, SYNRG +3 more |
About the gene
| Chromosome | 3: 101324205-101513241 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | Immunity, Innate immunity, Ubl conjugation pathway |
Function
Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.