IRF2 — Interferon regulatory factor 2

IRF2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IRF2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Chromatin regulation DNA/chromatin regulation	ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, KAT6A, MIER1 +12 more	View in SCUBA
CD8⁺ T cells	IFN-gamma Response Inflammation	CASP3, GBP5, IFI16, OPTN, SP100, SP140, TNFSF10, WIPF1	View in SCUBA
Gamma-delta T cells	T cell Survival T cell maturation	ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS +26 more
Innate lymphoid cells	Transcription RNA Processing RNA processing & translation	ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more	View in SCUBA
Monocytes	GIMAP activation Housekeeping	FGD2, GIMAP1, GIMAP4, GIMAP6, GIMAP7, GIMAP8, NAGK, P2RY13 +2 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Immune Survival Immune regulation	AGGF1, GOPC, GRAP2, LPAR5, MTAP, PDCD10, SENP7, SYNRG +3 more
Natural Killer cells	NK Homeostatic Survival Immune regulation	ACAP1, ARHGAP30, CAPN12, FYB1, GIMAP6, GPR174, SLFN5, STOM +1 more	View in SCUBA
Neutrophils	Innate DNA Sensing ISG Antiviral	AIM2, GIMAP4, IFI16, RNF213, SHISA5, SP110, TMEM154, TNFSF10 +1 more

About the gene

Chromosome	4: 184385702-184474558
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.