NF-κB Immune Survival
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub TNFAIP8 is an anti-apoptotic/immune regulatory gene linked to NF-κB and T cell survival. IRF2 is a key interferon regulatory factor. GRAP2 (GRID2IP/Gads) is a linker protein in TCR/cytokine signaling. VPS35 (retromer complex), PDCD10 (programmed cell death 10, also CCM3), SENP7 (SUMO protease), AGGF1 (angiogenesis/survival factor), LPAR5 (lysophosphatidic acid receptor 5, expressed on NK/T cells and relevant to immune activation), SYNRG, TTC1, GOPC, and MTAP. The combination of TNFAIP8 (NF-κB survival), IRF2 (interferon regulation), GRAP2 (TCR signaling adaptor), and LPAR5 (immune cell activation receptor) suggests an immune regulatory/survival program in MAIT cells. The neighbor M130 (CCR1/2/5 chemokine receptors) supports an immune cell state context.
Genes
AGGF1, GOPC, GRAP2, IRF2, LPAR5, MTAP, PDCD10, SENP7, SYNRG, TNFAIP8, TTC1, VPS35
Most correlated modules
- Chemokine Receptor Migration · correlation 0.89
- Nuclear regulatory housekeeping · correlation 0.84
- Chromatin Maintenance State · correlation 0.83
- mRNA Export & Processing · correlation 0.82
- T cell Survival Regulation · correlation 0.82
- Endosomal Actin Organization · correlation 0.81
- MAIT Effector Maturation · correlation 0.78
- Mitochondrial Biogenesis · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.