PBXIP1 — PBX homeobox interacting protein 1

PBXIP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PBXIP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Leukocyte Migration Signaling migration & adhesion	AP1S3, ARID5B, ATP2B1, CYBB, DOCK8, EMB, GLIPR1, IQGAP1 +5 more	View in SCUBA
CD4⁺ T cells	NF-kB feedback TCR/AP1/NFKb pathway	ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1 +8 more	View in SCUBA
Fibroblasts	Caveolae Mechanosensing Cytoskeletal	APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1 +10 more	View in SCUBA
Gamma-delta T cells	T Cell Development T cell maturation	ANK3, ATF7IP2, CERK, ERN1, FKBP11, LRIG1, MICAL2, PAG1 +4 more
Hematopoietic progenitor cells	Cytoskeletal Remodeling Cytoskeletal	AHNAK, ANXA1, ATP2B1, DPYSL3, FHL1, IDS, MBOAT7, MTURN +5 more
Innate lymphoid cells	IFN-driven ILC1 Activation Inflammation	AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more	View in SCUBA
Mucosal-associated invariant T cell	Co-transcriptional Splicing RNA processing & translation	C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5 +16 more

About the gene

Synonyms	HPIP
Chromosome	1: 154944076-154956123
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins

Function

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.