MBOAT7 — Membrane bound O-acyltransferase domain containing 7
MBOAT7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MBOAT7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Cytoskeletal Remodeling Cytoskeletal | AHNAK, ANXA1, ATP2B1, DPYSL3, FHL1, IDS, MTURN, PBXIP1 +5 more | |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1 +14 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
| Neutrophils | TLR Lipid Signaling Innate immunity | DGAT2, IFNAR1, LILRB3, NOTCH1, PPP1R3B, STEAP4, TLR1, TLR4 +1 more |
About the gene
| Synonyms | BB1, hMBOA-7, LENG4, LPIAT1, LPLAT, LPLAT11 |
|---|---|
| Chromosome | 19: 54173412-54189882 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.